Description

tert-Butyl 7-Hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate is a protected intermediate of significant value in advanced organic synthesis. This compound matters because it provides a versatile and stable building block for constructing complex heterocyclic scaffolds, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, or infectious diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, or insecticides that require a functionalized quinoline core structure.
• Material Science Precursor: Serves as a monomer or precursor for the synthesis of organic semiconductors, ligands for catalysis, or advanced polymers.
• Academic & Contract Research: Essential for medicinal chemistry programs in universities and CROs (Contract Research Organizations) exploring new chemical entities.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of target molecules containing the dihydroquinoline moiety.
• Ligand Synthesis: Used to prepare complex chelating agents or chiral auxiliaries for asymmetric catalysis.

Basic Information

Product Name	tert-Butyl 7-Hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate
CAS No.	676254-89-0
Molecular Formula	C₁₄H₁₉NO₃
Molecular Weight	249.31 g/mol
Synonyms	1-Boc-7-hydroxy-1,2,3,4-tetrahydroquinoline; tert-Butyl 7-hydroxy-1,2,3,4-tetrahydroquinoline-1-carboxylate; 7-Hydroxy-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester; 1,2,3,4-Tetrahydro-7-hydroxyquinoline-1-carboxylic acid tert-butyl ester; 1-N-Boc-7-hydroxy-1,2,3,4-tetrahydroquinoline; Boc-7-OH-THQ; 7-Hydroxy-N-Boc-1,2,3,4-tetrahydroquinoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.