Description

3,8-Diazabicyclo[3.2.1]Octane-2-Carboxylicacid,4-Oxo-,Methylester,(1R,2R,5S)-(9Ci) is a high-purity, stereochemically defined bicyclic lactam derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its complex, rigid molecular framework makes it an invaluable building block for synthesizing novel, structurally constrained active compounds. This product is primarily targeted at research and development teams in the pharmaceutical and biotechnology sectors, particularly those focused on neurology, oncology, and complex heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Neurological Drug Research: Used in the synthesis of potential drug candidates targeting complex neurological pathways due to its constrained bicyclic structure.
• Oncology Drug Discovery: Serves as a scaffold for creating novel molecules with potential anti-cancer activity.
• Protease Inhibitor Development: Its lactam core is applicable in designing inhibitors for various enzymatic targets.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective synthesis to introduce specific three-dimensional complexity.
• Academic & Contract Research: A valuable compound for methodological studies in organic and medicinal chemistry at research institutions and CROs.

Basic Information

Product Name	3,8-Diazabicyclo[3.2.1]Octane-2-Carboxylicacid,4-Oxo-,Methylester,(1R,2R,5S)-(9Ci)
CAS No.	676148-40-6
Molecular Formula	C9H12N2O3
Molecular Weight	196.20 g/mol
Synonyms	(1R,2R,5S)-Methyl 4-oxo-3,8-diazabicyclo[3.2.1]octane-2-carboxylate; (1R,2R,5S)-3,8-Diazabicyclo[3.2.1]octane-2-carboxylic acid, 4-oxo-, methyl ester; Methyl (1R,2R,5S)-4-oxo-3,8-diazabicyclo[3.2.1]octane-2-carboxylate; 676148-40-6; (1R,2R,5S)-4-Oxo-3,8-diazabicyclo[3.2.1]octane-2-carboxylic acid methyl ester; Bicyclic lactam ester intermediate
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems. We provide comprehensive analytical data to support your regulatory filings and ensure batch-to-batch consistency. Certificates of Analysis (COA) are supplied with each shipment, detailing purity, chiral purity, and impurity profiles as determined by HPLC, GC, and NMR. Our quality standards are designed to meet the rigorous demands of pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.