Description

Bno-Peg4-Ch2Ch2Br is a specialized bifunctional polyethylene glycol (PEG) derivative featuring a bromoalkyl end group and a tert-butyloxycarbonyl (Boc) protected amine. This compound is a crucial building block in the synthesis of complex molecules, offering a versatile linker for bioconjugation and the development of targeted drug delivery systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for creating antibody-drug conjugates (ADCs), peptide modifications, and functionalized polymers.

Application

• Bioconjugation Linker: A key intermediate for attaching cytotoxic drugs, fluorophores, or other payloads to antibodies, proteins, or peptides in ADC and diagnostic probe development.
• Polymer Chemistry: Serves as a functional initiator or monomer for synthesizing well-defined, telechelic PEG-based polymers and block copolymers with reactive end groups.
• Protease-Sensitive Linker Precursor: Used in the design of cleavable linkers for stimuli-responsive drug release mechanisms in targeted therapies.
• Surface Functionalization: Employed to modify nanoparticles, biosensors, and other material surfaces with amine-reactive groups for subsequent biomolecule immobilization.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a versatile building block for introducing PEG spacers and functional handles into synthetic peptides.
• Cross-linking Agent: Utilized to create covalent cross-links between molecules containing nucleophilic groups (e.g., thiols, amines).

Basic Information

Product Name	Bno-Peg4-Ch2Ch2Br
CAS No.	675606-48-1
Molecular Formula	C20H40BrNO7
Molecular Weight	486.44 g/mol
Synonyms	1-Bromo-2-{2-[2-(2-{2-[(tert-Butoxycarbonyl)amino]ethoxy}ethoxy)ethoxy]ethoxy}ethane; Boc-NH-PEG4-Br; Boc-Amino-PEG4-Bromide; 2-{2-[2-(2-{2-[(tert-Butoxycarbonyl)amino]ethoxy}ethoxy)ethoxy]ethoxy}ethyl Bromide; tert-Butyl N-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate; Boc-N-amido-PEG4-bromide; Boc-PEG4-Br; Amino-PEG4-Br Boc-protected
EINECS	Contact for details

Quality Control

Our Bno-Peg4-Ch2Ch2Br is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and Mass Spectrometry, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or CoA. The product is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.