Description

1-(tert-Butoxycarbonyl)-1H-Indole-3-Carboxylic Acid is a high-purity, protected indole derivative serving as a critical building block in advanced organic synthesis. This compound is essential for the efficient and selective construction of complex molecules, particularly in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and complex heterocycles.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Peptidomimetic Synthesis: Used to incorporate the indole scaffold into peptide backbones, creating stable analogs for biological evaluation.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and plant growth regulators with novel modes of action.
• Material Science: Employed in the creation of organic semiconductors, ligands for catalysis, and specialty polymers.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and for producing custom compounds for biological screening.

Basic Information

Product Name	1-(tert-Butoxycarbonyl)-1H-Indole-3-Carboxylic Acid
CAS No.	675606-20-9
Molecular Formula	C14H15NO4
Molecular Weight	261.27 g/mol
Synonyms	1-Boc-indole-3-carboxylic acid; 1H-Indole-3-carboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-; 1-[(tert-Butoxy)carbonyl]-1H-indole-3-carboxylic acid; 1-N-Boc-indole-3-carboxylic acid; Boc-Indole-3-COOH; tert-Butyl 3-carboxy-1H-indole-1-carboxylate; 3-Carboxy-1H-indole-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-(tert-Butoxycarbonyl)-1H-Indole-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high standards, including cGMP development and non-GMP research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and performance. Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.