Description

4,4-Difluorocyclohexylamine Hydrochloride is a high-purity, functionalized cyclohexylamine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic incorporation of fluorine atoms and a primary amine group, which are essential for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluorocyclohexyl moiety can enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials with tailored surface properties.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes and diagnostic agents in life science research.

Basic Information

Product Name	4,4-Difluorocyclohexylamine Hydrochloride
CAS No.	675112-70-6
Molecular Formula	C6H12ClF2N
Molecular Weight	171.62 g/mol
Synonyms	4,4-Difluorocyclohexanamine Hydrochloride; trans-4,4-Difluorocyclohexylamine Hydrochloride; cis-4,4-Difluorocyclohexylamine Hydrochloride; 4,4-Difluorocyclohexylammonium Chloride; 1-Amino-4,4-difluorocyclohexane Hydrochloride; 4,4-Difluoro-1-cyclohexanamine Hydrochloride; 4,4-Difluorocyclohexylamine HCl; 4,4-Difluorocyclohexylamine Hydrochloride Salt
EINECS	Contact for details

Quality Control

Our 4,4-Difluorocyclohexylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.