Description

Tetrahydro-Pyran-3-Ylamine Hydrochloride is a versatile chiral amine building block essential for modern pharmaceutical and fine chemical synthesis. Its value lies in the pyran ring structure, which serves as a key scaffold for developing bioactive molecules with improved metabolic stability and solubility profiles. This high-purity intermediate is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its amine functionality for creating novel active compounds.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to achieve high enantioselectivity.
• Peptidomimetics Research: The tetrahydro-pyran core is a valuable bioisostere in medicinal chemistry for designing peptide mimics with enhanced pharmacokinetic properties.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, flavors, and fragrances requiring specific chiral amine components.
• Academic and R&D: A valuable reagent for chemical research in universities and corporate R&D labs exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	Tetrahydro-Pyran-3-Ylamine Hydrochloride
CAS No.	675112-58-0
Molecular Formula	C6H14ClNO
Molecular Weight	151.63 g/mol
Synonyms	3-Aminotetrahydropyran Hydrochloride; Tetrahydro-2H-pyran-3-amine hydrochloride; 3-Pyranamine, tetrahydro-, hydrochloride; THP-3-amine HCl; 3-Aminooxane hydrochloride; Oxan-3-amine hydrochloride; Tetrahydropyran-3-ylamine hydrochloride
EINECS	Contact for details

Quality Control

Our Tetrahydro-Pyran-3-Ylamine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for advanced synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity (enantiomeric excess), and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, and we support customer audits and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.