Description

(4S)-4-Aminopyrrolidin-2-One Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its value lies in its role as a key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas like neurology and oncology. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in asymmetric synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of complex drug molecules, including protease inhibitors and other biologically active compounds.
• Asymmetric Synthesis: Used as a building block for constructing stereochemically defined pyrrolidine-based scaffolds in medicinal chemistry.
• Protease Inhibitor Research: Serves as a core structural component in the development of inhibitors targeting various enzymatic pathways.
• Neurological Drug Development: Employed in research for potential treatments targeting neurological disorders.
• Chemical Biology & Probe Development: Utilized in the creation of molecular probes to study biological systems and enzyme functions.
• Custom Synthesis & Scale-Up: A starting material for contract research and manufacturing services (CRO/CMO) requiring gram to kilogram quantities under cGMP guidelines.

Basic Information

Product Name	(4S)-4-Aminopyrrolidin-2-One Hydrochloride
CAS No.	672883-63-5
Molecular Formula	C4H9N2O·HCl
Molecular Weight	136.59 g/mol
Synonyms	(4S)-4-Aminopyrrolidin-2-one HCl; (S)-4-Amino-2-pyrrolidinone hydrochloride; L-4-Aminopyrrolidin-2-one hydrochloride; (S)-4-Aminodihydro-2(3H)-furanone hydrochloride; 4-Amino-L-proline lactam hydrochloride; 2-Pyrrolidinone, 4-amino-, hydrochloride, (4S)-; (S)-4-Aminopyrrolidin-2-one monohydrochloride
EINECS	Contact for details

Quality Control

Our (4S)-4-Aminopyrrolidin-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98%), chiral excess, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.