Description

trans-n-Fmoc-1,4-Cyclohexanediamine Hydrochloride is a high-purity, protected diamine building block essential for advanced organic synthesis. This compound is critical for introducing a rigid, chiral cyclohexane scaffold into peptide and peptidomimetic structures, enabling the development of molecules with enhanced metabolic stability and specific conformational properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for creating novel therapeutic agents targeting GPCRs and proteases.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for incorporating the constrained 1,4-diaminocyclohexane moiety into peptide chains to modulate backbone flexibility and biological activity.
• Peptidomimetic Drug Discovery: Serves as a crucial scaffold in the design and synthesis of non-peptide compounds that mimic peptide function, improving oral bioavailability and stability.
• Combinatorial Chemistry Libraries: Used to generate diverse chemical libraries for high-throughput screening against various biological targets.
• Linker and Spacer Molecule: Employed in bioconjugation and the development of antibody-drug conjugates (ADCs) due to its amine functionality and stable cyclohexane core.
• Organocatalyst Synthesis: Acts as a precursor for chiral diamine ligands and catalysts used in asymmetric synthesis.
• Material Science Research: A monomer for synthesizing specialized polyamides and polymers with unique thermal and mechanical properties.

Basic Information

Product Name	trans-n-Fmoc-1,4-Cyclohexanediamine Hydrochloride
CAS No.	672310-17-7
Molecular Formula	C₂₂H₂₇ClN₂O₂
Molecular Weight	386.91 g/mol
Synonyms	trans-1-Fmoc-4-aminocyclohexylamine hydrochloride; (1r,4r)-4-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]cyclohexanamine hydrochloride; Fmoc-trans-1,4-ACHC-OH.HCl; N-[(1r,4r)-4-Aminocyclohexyl]carbamic acid 9H-fluoren-9-ylmethyl ester hydrochloride; trans-4-(Fmoc-amino)cyclohexylamine hydrochloride; Fmoc-DACH hydrochloride (trans); trans-1,4-BAC-Fmoc hydrochloride
EINECS	Contact for details

Quality Control

Our trans-n-Fmoc-1,4-Cyclohexanediamine Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥98.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.