Description

4-(Quinoline-3-Carbonyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine and quinoline-based molecular architecture. This compound is of significant value for its role as a key building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry research and development. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel therapeutic agents, especially within the fields of oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, particularly those targeting protein kinases and other enzymatic pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• API (Active Pharmaceutical Ingredient) Development: Used in the research and process development stages for new active pharmaceutical ingredients, especially in oncology and CNS therapeutic areas.
• Chemical Biology Probes: Employed in the design and synthesis of chemical probes for studying biological mechanisms and target validation.
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke synthetic services to the pharma and biotech industries.

Basic Information

Product Name	4-(Quinoline-3-Carbonyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	669074-89-9
Molecular Formula	C20H24N2O3
Molecular Weight	340.42 g/mol
Synonyms	1-Boc-4-(quinoline-3-carbonyl)piperidine; tert-Butyl 4-(quinoline-3-carbonyl)piperidine-1-carboxylate; 4-(3-Quinolinecarbonyl)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester; 1,1-Dimethylethyl 4-(3-quinolinylcarbonyl)-1-piperidinecarboxylate; 4-(Quinolin-3-ylcarbonyl)piperidine-1-carboxylic Acid tert-Butyl Ester; 1-Boc-4-(3-quinolylcarbonyl)piperidine; 4-(3-Quinolylcarbonyl)piperidine-1-carboxylic Acid tert-Butyl Ester; Piperidine-1-carboxylic acid, 4-(3-quinolinylcarbonyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 4-(Quinoline-3-Carbonyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.