Description

1,3A-Methano-3Ah-Indene-7A(1H)-Methanol,Hexahydro-3-Hydroxy-8-Methylene-,(1R,3S,3As,7Ar)-Rel-(9Ci) is a high-purity, stereochemically defined synthetic intermediate of significant value in advanced organic synthesis. Its complex, polycyclic structure containing hydroxyl and methylene groups makes it a versatile chiral building block for constructing pharmacologically active molecules. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries seeking to develop novel therapeutic agents or complex natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or anti-inflammatory targets.
• Asymmetric Catalysis Research: Used as a substrate or ligand precursor in the development and testing of new asymmetric catalytic reactions due to its defined stereocenters.
• Natural Product Synthesis: Acts as a key intermediate in the total synthesis of complex natural products with indane or related polycyclic frameworks.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and for introducing specific three-dimensional complexity into drug candidate molecules.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals, agrochemicals, and advanced materials requiring high stereochemical purity.

Basic Information

Product Name	1,3A-Methano-3Ah-Indene-7A(1H)-Methanol,Hexahydro-3-Hydroxy-8-Methylene-,(1R,3S,3As,7Ar)-Rel-(9Ci)
CAS No.	667938-53-6
Molecular Formula	C12H18O2
Molecular Weight	194.27 g/mol
Synonyms	(1R,3S,3aS,7aR)-rel-Hexahydro-3-hydroxy-8-methylene-1,3a-methano-3aH-indene-7a(1H)-methanol; rel-(1R,3S,3aS,7aR)-Octahydro-3-hydroxy-8-methylene-1,3a-methano-3aH-indene-7a-methanol; Hexahydro-3-hydroxy-8-methylene-1,3a-methano-3aH-indene-7a(1H)-methanol, (1R,3S,3aS,7aR)-rel-; 667938-53-6; Chiral Indane Methanol Derivative; Polycyclic Alcohol Intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure high chemical and stereochemical purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.