Description

Phenol, 3-(Difluoromethyl)-4-Ethoxy-2-Fluoro- (9Ci) is a specialized fluorinated phenolic compound with a unique substitution pattern, making it a valuable advanced intermediate in synthetic organic chemistry. Its structure is engineered to introduce specific fluorine-containing motifs, which are critical for modulating the physicochemical and biological properties of target molecules. This high-purity intermediate is primarily sought by R&D and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl and fluoro groups enhance bioavailability and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced materials with tailored surface properties.
• Liquid Crystal & OLED Materials: Potential precursor for fluorine-containing components in electronic display materials and organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Useful in constructing molecular probes and tags for studying biochemical pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-value fluorinated intermediates.

Basic Information

Product Name	Phenol, 3-(Difluoromethyl)-4-Ethoxy-2-Fluoro- (9Ci)
CAS No.	667899-92-5
Molecular Formula	C9H9F3O2
Molecular Weight	206.16 g/mol
Synonyms	3-(Difluoromethyl)-4-ethoxy-2-fluorophenol; 2-Fluoro-3-(difluoromethyl)-4-ethoxyphenol; 4-ethoxy-2-fluoro-3-(difluoromethyl)phenol; Phenol, 3-(difluoromethyl)-4-ethoxy-2-fluoro-; 667899-92-5; Fluorinated phenolic ether intermediate
EINECS	Contact for details

Quality Control

Every batch of Phenol, 3-(Difluoromethyl)-4-Ethoxy-2-Fluoro- (9Ci) is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and consistency for your critical R&D and scale-up processes. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment, supporting compliance with cGMP and ISO 9001 standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.