Description

8-Chloro-2-(2-Hydroxy-Phenyl)-Quinoline-4-Carboxylic Acid is a high-purity, functionalized quinoline derivative of significant interest in advanced organic synthesis. This compound matters as a versatile and critical pharmaceutical intermediate for the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to build complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, particularly those targeting neurological or inflammatory pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides due to its bioactive quinoline core.
• Ligand Synthesis: Acts as a precursor for creating complex chelating ligands used in catalysis or metal-organic frameworks (MOFs).
• Fluorescent Probe Development: The quinoline structure makes it suitable for modifying into dyes or sensors for analytical and diagnostic applications.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and novel compound library generation.
• Material Science: Investigated as a monomer or additive for creating specialized polymers with unique optical or electronic properties.

Basic Information

Product Name	8-Chloro-2-(2-Hydroxy-Phenyl)-Quinoline-4-Carboxylic Acid
CAS No.	667412-65-9
Molecular Formula	C₁₇H₁₀ClNO₃
Molecular Weight	311.72 g/mol
Synonyms	8-Chloro-2-(2-hydroxyphenyl)quinoline-4-carboxylic acid; 2-(2-Hydroxyphenyl)-8-chloroquinoline-4-carboxylic acid; 8-Chloro-2-(2-hydroxy-phenyl)-4-quinolinecarboxylic acid; Quinoline-4-carboxylic acid, 8-chloro-2-(2-hydroxyphenyl)-; 667412-65-9; 8-Cl-2-(2-OH-Ph)-QCA
EINECS	Contact for details

Quality Control

Our 8-Chloro-2-(2-Hydroxy-Phenyl)-Quinoline-4-Carboxylic Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.