Description

tert-Butyl 3H-Spiro[Isobenzofuran-1,4'-Piperidine]-1'-Carboxylate CAS NO 663622-87-5 is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and heterocyclic architecture. This compound is of critical importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapies. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities (NCEs).

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug molecules, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Used extensively in R&D for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: A key scaffold for constructing the core structure of potential APIs in therapeutic areas such as psychiatry, neurology, and analgesia.
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Chemical Biology Probes: Can be utilized to develop tool compounds for studying biological targets and mechanisms of action.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial compounds for clinical trials.

Basic Information

Product Name	tert-Butyl 3H-Spiro[Isobenzofuran-1,4'-Piperidine]-1'-Carboxylate
CAS No.	663622-87-5
Molecular Formula	C17H21NO3
Molecular Weight	287.35 g/mol
Synonyms	1'-BOC-3H-Spiro[isobenzofuran-1,4'-piperidine]; tert-Butyl 1-oxa-2-azaspiro[4.5]dec-2-ene-2-carboxylate (related structural name); 1,4'-Piperidine]-1'-carboxylic acid, 3H-spiro[isobenzofuran-1, 1,1-dimethylethyl ester; BOC-Spiro[isobenzofuran-1(3H),4'-piperidine]; 3H-Spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 1-oxa-2-azaspiro[4.5]deca-2,6,8-trien-2-carboxylate; 663622-87-5; BOC-protected spirocyclic isobenzofuran-piperidine.
EINECS	Contact for details

Quality Control

Our tert-Butyl 3H-Spiro[Isobenzofuran-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.