Description

2-Bromo-8-Chloro-4-(Trifluoromethyl)Quinoline-3-Carboxylic Acid is a high-value, multi-functionalized quinoline derivative that serves as a critical synthetic intermediate. This compound matters for its role in constructing complex molecular architectures, particularly in the development of advanced pharmaceuticals and agrochemicals. Pharmaceutical R&D and fine chemical synthesis laboratories need it for creating novel active ingredients, leveraging its unique halogen and trifluoromethyl substitution pattern for modulating bioactivity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and anti-inflammatory compounds.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the quinoline core and halogen atoms contribute to biological activity.
• Material Science Precursor: Serves as a starting material for synthesizing functionalized organic molecules used in organic light-emitting diodes (OLEDs) and other advanced materials.
• Chemical Biology Probe: Utilized in research to create molecular probes for studying enzyme function and biological pathways due to its modifiable carboxylic acid group.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	2-Bromo-8-Chloro-4-(Trifluoromethyl)Quinoline-3-Carboxylic Acid
CAS No.	663193-41-7
Molecular Formula	C11H4BrClF3NO2
Molecular Weight	354.51 g/mol
Synonyms	2-Bromo-8-chloro-4-(trifluoromethyl)quinoline-3-carboxylic acid; 3-Quinolinecarboxylic acid, 2-bromo-8-chloro-4-(trifluoromethyl)-; 663193-41-7; 2-Bromo-8-chloro-4-trifluoromethylquinoline-3-carboxylic acid; Quinoline-3-carboxylic acid, 2-bromo-8-chloro-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Bromo-8-Chloro-4-(Trifluoromethyl)Quinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.