Description

(2S)-2-(Phenoxymethyl)Morpholine Hcl CAS NO 661470-52-6 is a high-purity chiral building block and pharmaceutical intermediate. This compound is critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and advanced fine chemicals. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and specialty chemical producers focused on developing novel therapeutics and high-value chemical entities.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and production of enantiomerically pure drugs, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• API Development: Serves as a core structural motif in the synthesis of potential new chemical entities (NCEs) during drug discovery and preclinical development.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals where precise stereochemistry is required for functionality.
• Academic & Industrial Research: A valuable reagent for methodological studies in organic and medicinal chemistry focused on morpholine and ether-containing compounds.

Basic Information

Product Name	(2S)-2-(Phenoxymethyl)Morpholine Hydrochloride
CAS No.	661470-52-6
Molecular Formula	C11H15NO2·HCl
Molecular Weight	229.70 g/mol (Free base: 193.24 g/mol)
Synonyms	(S)-2-(Phenoxymethyl)morpholine hydrochloride; (2S)-2-(Phenoxymethyl)-1,4-oxazinane hydrochloride; Morpholine, 2-(phenoxymethyl)-, hydrochloride, (2S)-; L-2-(Phenoxymethyl)morpholine HCl; (S)-(-)-2-(Phenoxymethyl)morpholine hydrochloride; (S)-2-(Phenoxymethyl)morpholine HCl salt; (S)-2-(Phenoxymethyl)-1,4-oxazine hydrochloride
EINECS	Contact for details

Quality Control

Our (2S)-2-(Phenoxymethyl)Morpholine Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.