Description

Isoxazole, 3-[[[5-(Difluoromethoxy)-1-Methyl-3-(Trifluoromethyl)-1H-Pyrazol-4-Yl]Methyl]Thio]-4,5-Dihydro-5,5-Dimethyl- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its complex heterocyclic structure, which incorporates multiple fluorine atoms and a thioether linkage, making it a key building block in modern synthetic chemistry. It is primarily sought by R&D and production teams in the agrochemical and pharmaceutical industries for the development of novel active ingredients.

Application

• Agrochemical Intermediate: A critical precursor in the synthesis of next-generation insecticides and herbicides, leveraging its unique fluorinated pyrazole-isoxazole scaffold.
• Pharmaceutical Research: Serves as a sophisticated building block for medicinal chemistry programs targeting new small-molecule therapeutics.
• Chemical Synthesis: Used in advanced organic synthesis for constructing complex molecules requiring specific fluorine-substituted heterocycles.
• Crop Protection Formulations: Incorporated into the development pipeline for novel crop protection agents with enhanced efficacy and environmental profiles.

Basic Information

Product Name	Isoxazole, 3-[[[5-(Difluoromethoxy)-1-Methyl-3-(Trifluoromethyl)-1H-Pyrazol-4-Yl]Methyl]Thio]-4,5-Dihydro-5,5-Dimethyl-
CAS No.	656825-92-2
Molecular Formula	C13H14F5N3O2S
Molecular Weight	395.33 g/mol
Synonyms	3-(((5-(Difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)thio)-4,5-dihydro-5,5-dimethylisoxazole; 5,5-Dimethyl-3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydroisoxazole; 4,5-Dihydro-5,5-dimethyl-3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]isoxazole; CAS 656825-92-2; Difluoromethoxy-pyrazole-isoxazole intermediate; Fluorinated pyrazole-isoxazole thioether.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support development and scale-up with custom purity grades upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.