Description

2H-Indol-2-One,3-Fluoro-1,3-Dihydro-3-Methyl-,(3R)-(9Ci) is a chiral, fluorinated indolinone derivative, a sophisticated building block of significant interest in advanced organic synthesis. Its value lies in the precise stereochemistry and fluorine substitution, which are critical for modulating the biological activity and physicochemical properties of target molecules. This high-purity intermediate is primarily needed by pharmaceutical R&D and fine chemical synthesis laboratories for the development of novel active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies, enabling the exploration of fluorinated analogs.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, agrochemicals, and advanced materials requiring specific fluorinated motifs.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical manufacturing.

Basic Information

Product Name	2H-Indol-2-One,3-Fluoro-1,3-Dihydro-3-Methyl-,(3R)-(9Ci)
CAS No.	655224-18-3
Molecular Formula	C9H8FNO
Molecular Weight	165.16 g/mol
Synonyms	(3R)-3-Fluoro-3-methylindolin-2-one; (R)-3-Fluoro-3-methylindolin-2-one; 3-Fluoro-3-methyl-2-indolinone, (3R)-; 3-Fluoro-3-methyl-1,3-dihydro-2H-indol-2-one, (3R)-; (R)-3-Fluoro-3-methyl-1,3-dihydro-2H-indol-2-one; 655224-18-3; (3R)-3-Fluoro-3-methyl-2-oxindole; (R)-3-Fluoro-3-methyl-2-oxindole
EINECS	Contact for details

Quality Control

Our 2H-Indol-2-One,3-Fluoro-1,3-Dihydro-3-Methyl-,(3R)-(9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure compliance with exacting R&D and cGMP-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and chiral purity is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.