Description

3-Quinolineethanol, 6-Bromo-α-[2-(Dimethylamino)Ethyl]-2-Methoxy-α-1-Naphthalenyl-β-Phenyl-, (αr,βr)-Rel- is a complex, high-purity chiral organic compound of significant interest in advanced pharmaceutical research and development. Its intricate molecular architecture, featuring quinoline, naphthalene, and phenyl moieties, makes it a valuable advanced pharmaceutical intermediate for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors working on targeted therapies.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a critical building block for the development of new drug candidates, particularly in oncology and central nervous system (CNS) research.
• Chiral Auxiliary/Precursor: Its defined stereochemistry ((αr,βr)-Rel-) makes it valuable for constructing complex molecules with specific three-dimensional configurations required for biological activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for potential commercial manufacturing.
• Reference Standard: High-purity grades can be used as an analytical standard for quality control and method validation in API production.
• Academic & Institutional Research: Utilized in universities and research institutes for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	3-Quinolineethanol, 6-Bromo-α-[2-(Dimethylamino)Ethyl]-2-Methoxy-α-1-Naphthalenyl-β-Phenyl-, (αr,βr)-Rel-
CAS No.	654653-92-6
Molecular Formula	C32H33BrN2O2
Molecular Weight	557.53 g/mol
Synonyms	rel-(αR,βR)-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-(1-naphthyl)-β-phenyl-3-quinolineethanol; (αR,βR)-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-(naphthalen-1-yl)-β-phenylquinoline-3-ethanol; 6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-(1-naphthyl)-β-phenyl-3-quinolineethanol (rel-(αR,βR)-); BRD4 Inhibitor Intermediate; BET Bromodomain Inhibitor Precursor
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP-compliant manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storage under an inert atmosphere (e.g., nitrogen or argon) to maintain stability. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.