Description

1(2H)-Naphthalenone,3,4-Dihydro-2-(Hydroxymethyl)-,(2S)-(9Ci) is a chiral, substituted tetralone derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and high-value pharmaceutical intermediate and chiral building block for constructing complex molecular architectures. It is primarily sought by R&D and production teams in the pharmaceutical and fine chemical industries for the development of active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug molecules, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Chiral Building Block: Utilized in asymmetric synthesis to introduce stereochemical complexity into target molecules, leveraging the (2S) configuration.
• Organic Synthesis Research: Serves as a starting material or intermediate in academic and industrial research for novel heterocyclic and polycyclic compound development.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, including advanced materials, agrochemicals, and flavors & fragrances where specific stereochemistry is required.
• Process Chemistry Development: Employed in route scouting and optimization for scalable API manufacturing processes.

Basic Information

Product Name	1(2H)-Naphthalenone,3,4-Dihydro-2-(Hydroxymethyl)-,(2S)-(9Ci)
CAS No.	648903-56-4
Molecular Formula	C11H12O2
Molecular Weight	176.21 g/mol
Synonyms	(2S)-3,4-Dihydro-2-(hydroxymethyl)-1(2H)-naphthalenone; (S)-3,4-Dihydro-2-(hydroxymethyl)-1(2H)-naphthalenone; (S)-2-(Hydroxymethyl)-3,4-dihydro-1(2H)-naphthalenone; (S)-2-(Hydroxymethyl)-α-tetralone; (S)-α-Tetralone-2-methanol; Chiral Tetralone Derivative; (2S)-2-Hydroxymethyl-α-tetralone
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chemical purity. Quality is verified through comprehensive analytical methods including HPLC for assay and impurity profiling, chiral analysis to confirm enantiomeric excess, and standard identification tests. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support development and commercial projects requiring compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere if necessary and opened only in a moisture-controlled environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.