Description

2-Azetidinecarboxylic Acid, Hydrochloride, (2R)- is a high-purity, enantiomerically pure building block essential for advanced organic synthesis. This compound is a key chiral intermediate in the development of novel pharmaceuticals and bioactive molecules, particularly in the field of peptidomimetics and constrained amino acid analogs. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of protease inhibitors, enzyme modulators, and other therapeutic agents.
• Peptidomimetic Research: Used to introduce the constrained azetidine ring into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a starting material or building block in stereoselective chemical reactions to create complex chiral molecules.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and protein function.
• Agrochemical Development: Potential use as an intermediate in the research and development of new, chiral active ingredients for crop protection.
• Academic & Industrial R&D: Fundamental building block for exploratory chemistry in both academic laboratories and industrial R&D departments.

Basic Information

Product Name	2-Azetidinecarboxylic Acid, Hydrochloride, (2R)-
CAS No.	647854-72-6
Molecular Formula	C4H8ClNO2
Molecular Weight	137.56 g/mol
Synonyms	(R)-2-Azetidinecarboxylic acid hydrochloride; (R)-Azetidine-2-carboxylic acid hydrochloride; D-Azetidine-2-carboxylic acid HCl; (2R)-Azetidine-2-carboxylic acid hydrochloride; (R)-PCA hydrochloride (Proline analog); (R)-Azc-HCl; (2R)-1-Azabicyclo[1.1.0]butane-2-carboxylic acid, hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Azetidinecarboxylic Acid, Hydrochloride, (2R)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.