Description

2-Oxaspiro[4.4]Nonan-1-One,6-Hydroxy-6-(1-Methylethyl)-,(5R,6S)-Rel-(9Ci) is a high-purity, stereochemically defined spirocyclic lactone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of complex pharmaceutical molecules and fine chemicals, offering a rigid, functionalized scaffold. It is primarily needed by research and development chemists, process development teams, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated molecular architectures into their target compounds.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex spirocyclic or fused-ring systems.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where its unique structure can contribute to biological activity and selectivity.
• Fine Chemical Production: Acts as a precursor in the manufacture of specialty chemicals, including fragrances, flavors, and advanced materials with specific stereochemical requirements.
• Academic & Industrial Research: A valuable tool for methodological development in organic chemistry, including studies on asymmetric synthesis, ring-forming reactions, and catalysis.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production, where consistent quality and stereochemical purity are paramount.

Basic Information

Item	Detail
Product Name	2-Oxaspiro[4.4]Nonan-1-One,6-Hydroxy-6-(1-Methylethyl)-,(5R,6S)-Rel-(9Ci)
CAS No.	643754-20-5
Molecular Formula	C11H18O3
Molecular Weight	198.26 g/mol
Synonyms	(5R,6S)-6-Hydroxy-6-isopropyl-2-oxaspiro[4.4]nonan-1-one; rel-(5R,6S)-6-Hydroxy-6-(1-methylethyl)-2-oxaspiro[4.4]nonan-1-one; 6-Hydroxy-6-isopropyl-2-oxaspiro[4.4]nonan-1-one (relative stereochemistry); Spirocyclic lactone intermediate; Chiral spiro lactone; 643754-20-5
EINECS	Contact for details

Quality Control

Our production of 2-Oxaspiro[4.4]Nonan-1-One,6-Hydroxy-6-(1-Methylethyl)-,(5R,6S)-Rel-(9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high stereochemical purity. Each lot undergoes comprehensive analysis using advanced techniques such as HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and isomeric composition. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (for specified isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.