Description

2-Oxaspiro[4.4]Nonan-1-One,6-Hydroxy-6,7,7-Trimethyl-,(5R,6R)-Rel-(9Ci) is a high-purity, stereochemically defined spirocyclic lactone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of complex pharmaceutical molecules and fine chemicals, where precise stereochemistry is critical for biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex spirocyclic or fused-ring systems.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where its unique spiro structure can contribute to new modes of action.
• Fine Chemical Production: Acts as a specialized precursor for high-value fragrance ingredients, flavors, and performance materials that benefit from its rigid molecular framework.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including asymmetric synthesis, ring-opening reactions, and the construction of oxygen-containing heterocycles.
• Material Science Research: Investigated as a monomer or cross-linking agent for developing polymers with specific thermal or mechanical properties derived from its spirocyclic core.

Basic Information

Item	Details
Product Name	2-Oxaspiro[4.4]Nonan-1-One,6-Hydroxy-6,7,7-Trimethyl-,(5R,6R)-Rel-(9Ci)
CAS No.	643754-13-6
Molecular Formula	C11H18O3
Molecular Weight	198.26 g/mol
Synonyms	6-Hydroxy-6,7,7-trimethyl-2-oxaspiro[4.4]nonan-1-one; (5R,6R)-rel-6-Hydroxy-6,7,7-trimethyl-2-oxaspiro[4.4]nonan-1-one; Trimethylhydroxyspirolactone; Spiro[4.4]nonane-1-one, 6-hydroxy-6,7,7-trimethyl-2-oxa-, (5R,6R)-rel-; Chiral spirocyclic lactone intermediate; 643754-13-6; (rel)-(5R,6R)-6-Hydroxy-6,7,7-trimethyl-2-oxaspiro[4.4]nonan-1-one
EINECS	Contact for details

Quality Control

Our 2-Oxaspiro[4.4]Nonan-1-One,6-Hydroxy-6,7,7-Trimethyl-,(5R,6R)-Rel-(9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure high chemical and stereochemical purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.