Description

8-(Trifluoromethyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one is a high-value, fluorinated heterocyclic compound that serves as a critical building block in advanced organic synthesis. Its unique pyrroloquinazolinone scaffold, functionalized with a trifluoromethyl group, provides distinct electronic and steric properties essential for developing novel bioactive molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science: Serves as a monomer or functional additive in the research of specialty polymers and organic electronic materials, such as OLEDs.
• Chemical Biology Probe: Utilized as a scaffold for designing molecular probes to study enzyme function and biological pathways in academic and industrial research settings.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical manufacturers offering bespoke synthesis services for clients in life sciences.

Basic Information

Product Name	8-(Trifluoromethyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
CAS No.	642491-87-0
Molecular Formula	C₁₃H₉F₃N₂O
Molecular Weight	266.22 g/mol
Synonyms	8-(Trifluoromethyl)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-9-one; 8-Trifluoromethyl-2,3-dihydro-1H-pyrrolo[2,1-b]quinazolin-9-one; 1H-Pyrrolo[2,1-b]quinazolin-9-one, 2,3-dihydro-8-(trifluoromethyl)-; Pyrrolo[2,1-b]quinazolin-9(1H)-one, 8-(trifluoromethyl)-2,3-dihydro-; 642491-87-0; TFMPQ; Trifluoromethyl DHPQ
EINECS	Contact for details

Quality Control

Every batch of 8-(Trifluoromethyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.