Description

8-Chloro-4-Oxo-5-(Trifluoromethyl)-1,4-Dihydroquinoline-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its quinoline-3-carboxylic acid core structure. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting complex therapeutic areas. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing next-generation quinolone-based drugs and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and production of fluorinated quinolone antibiotics and other bioactive molecules.
• API Synthesis: Serves as a crucial precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Agrochemical Research: Used in the development of new agrochemicals, such as herbicides and pesticides, leveraging its unique halogenated and fluorinated structure.
• Chemical Research & Development: Employed in organic synthesis and medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fluorine Chemistry: Valuable for introducing the trifluoromethyl group into complex molecular architectures, a common motif in modern drug design.

Basic Information

Product Name	8-Chloro-4-Oxo-5-(Trifluoromethyl)-1,4-Dihydroquinoline-3-Carboxylic Acid
CAS No.	641993-18-2
Molecular Formula	C11H5ClF3NO3
Molecular Weight	291.61 g/mol
Synonyms	8-Chloro-5-(trifluoromethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 8-Chloro-5-trifluoromethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid; 1,4-Dihydro-8-chloro-5-(trifluoromethyl)-4-oxo-3-quinolinecarboxylic Acid; 3-Quinolinecarboxylic acid, 1,4-dihydro-8-chloro-5-(trifluoromethyl)-4-oxo-; 8-Chloro-5-trifluoromethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 641993-18-2
EINECS	Contact for details

Quality Control

Our 8-Chloro-4-Oxo-5-(Trifluoromethyl)-1,4-Dihydroquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.