Description

4(3H)-Quinazolinone, 8-Methoxy-2-(Phenylmethyl)-3-[4-[2,2,2-Trifluoro-1-Hydroxy-1-(Trifluoromethyl)Ethyl]Phenyl]- is a high-purity, advanced pharmaceutical intermediate characterized by a complex heterocyclic structure incorporating multiple trifluoromethyl groups. This compound matters for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and oncological pathways. Pharmaceutical R&D and fine chemical synthesis companies need this material to develop next-generation therapeutics with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key precursor in the research and development of new drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize lead compounds for potency and selectivity.
• Fluorinated Compound Synthesis: Serves as a valuable scaffold for introducing multiple fluorine atoms, a common strategy to improve drug-like properties such as membrane permeability and metabolic resistance.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for investigating novel heterocyclic chemistry and bioorganic mechanisms.

Basic Information

Item	Details
Product Name	4(3H)-Quinazolinone, 8-Methoxy-2-(Phenylmethyl)-3-[4-[2,2,2-Trifluoro-1-Hydroxy-1-(Trifluoromethyl)Ethyl]Phenyl]-
CAS No.	637345-51-8
Molecular Formula	C25H18F6N2O2
Molecular Weight	492.42 g/mol
Synonyms	8-Methoxy-2-benzyl-3-[4-[1-hydroxy-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]phenyl]quinazolin-4(3H)-one; 2-Benzyl-8-methoxy-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4(3H)-quinazolinone; 4(3H)-Quinazolinone, 8-methoxy-2-(phenylmethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-; 637345-51-8; 8-Methoxy-2-benzyl-3-(4-(1-hydroxy-2,2,2-trifluoro-1-(trifluoromethyl)ethyl)phenyl)quinazolin-4(3H)-one
EINECS	Contact for details

Quality Control

Our 4(3H)-Quinazolinone derivative is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. The container must be kept tightly closed to protect this light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.