Description

1-Boc-3-Azabicyclo[3.2.1]Octane-8-Methanol is a high-purity, protected amine building block of significant interest in advanced organic synthesis. Its value lies in its rigid bicyclic scaffold and functional handles, which are crucial for constructing complex molecular architectures with precise stereochemistry. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral targets.
• Medicinal Chemistry Scaffold: Used to explore structure-activity relationships (SAR) by introducing diverse substituents onto the nitrogen and alcohol functional groups.
• Peptidomimetic Synthesis: Serves as a constrained, non-natural amino acid analog to enhance the metabolic stability and bioavailability of peptide-based drug candidates.
• Ligand and Catalyst Development: Employed in the synthesis of sophisticated chiral ligands and organocatalysts for asymmetric synthesis.
• Agrochemical Research: Utilized as a building block for novel herbicides, fungicides, and plant growth regulators requiring specific three-dimensional shapes.
• Academic and Contract Research: A valuable reagent for methodology development and the synthesis of complex natural products or molecular probes in academic and CRO settings.

Basic Information

Product Name	1-Boc-3-Azabicyclo[3.2.1]Octane-8-Methanol
CAS No.	637301-16-7
Molecular Formula	C₁₃H₂₃NO₃
Molecular Weight	241.33 g/mol
Synonyms	8-(Hydroxymethyl)-3-azabicyclo[3.2.1]octane-3-carboxylic acid tert-butyl ester; tert-Butyl 8-(hydroxymethyl)-3-azabicyclo[3.2.1]octane-3-carboxylate; 3-Boc-3-azabicyclo[3.2.1]octane-8-methanol; 3-Azabicyclo[3.2.1]octane-8-methanol, 1,1-dimethylethyl ester; 1-Boc-3-aza-bicyclo[3.2.1]octane-8-methanol; Bicyclo[3.2.1]octane-8-methanol, 3-[(1,1-dimethylethoxy)carbonyl]-; 1-Boc-3-aza-bicyclo[3.2.1]octan-8-yl-methanol
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Azabicyclo[3.2.1]Octane-8-Methanol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.