Description

(S)-α-(4-Bromobenzyl)-Proline-Hcl is a high-purity chiral proline derivative, a critical building block in modern pharmaceutical synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs), particularly those targeting complex diseases. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the synthesis of peptidomimetics, protease inhibitors, and other novel therapeutic agents where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Peptidomimetic Research: Used in the design and development of peptide-like molecules for drug discovery.
• Protease Inhibitor Development: Serves as a core structural component in inhibitors targeting specific enzymes.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand in catalytic asymmetric reactions.
• Medicinal Chemistry: A valuable building block for constructing complex molecular architectures in lead optimization.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development.

Basic Information

Product Name	(S)-α-(4-Bromobenzyl)-Proline-Hcl
CAS No.	637020-93-0
Molecular Formula	C₁₃H₁₆BrNO₂ • HCl
Molecular Weight	334.64 g/mol (Free base: 298.18 g/mol)
Synonyms	(S)-1-[(4-Bromophenyl)methyl]pyrrolidine-2-carboxylic acid hydrochloride; (S)-α-[(4-Bromophenyl)methyl]-L-proline hydrochloride; (S)-4-Bromobenzylproline hydrochloride; L-Proline, 1-[(4-bromophenyl)methyl]-, hydrochloride (1:1); (S)-A-(4-Bromobenzyl)proline HCl; (S)-Proline, α-(4-bromobenzyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-α-(4-Bromobenzyl)-Proline-Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.