Description

(S)-α-(2-Bromobenzyl)-Proline-Hcl is a high-purity chiral proline derivative, serving as a critical building block in modern organic synthesis. Its value lies in its role as a sophisticated intermediate for constructing complex molecules with defined stereochemistry, essential for achieving desired biological activity. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing active pharmaceutical ingredients (APIs), peptide mimetics, and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetic Chemistry: Used to introduce constrained proline analogs into peptide backbones to enhance metabolic stability and receptor selectivity.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations to induce enantioselectivity.
• Medicinal Chemistry Research: Building block for creating focused libraries of compounds for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for the scale-up and cGMP production of advanced intermediates for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for methodological development in organic chemistry and chemical biology.

Basic Information

Product Name	(S)-α-(2-Bromobenzyl)-Proline Hydrochloride
CAS No.	637020-88-3
Molecular Formula	C₁₃H₁₆BrNO₂·HCl
Molecular Weight	334.64 g/mol
Synonyms	(S)-2-((2-Bromobenzyl)amino)-5-chloropentanoic acid hydrochloride; (S)-α-((2-Bromophenyl)methyl)-1-pyrrolidinecarboxylic acid hydrochloride; L-Proline, α-[(2-bromophenyl)methyl]-, hydrochloride (1:1); (S)-2-(2-Bromobenzyl)proline hydrochloride; (2S)-2-[(2-Bromophenyl)methyl]pyrrolidine-2-carboxylic acid hydrochloride; Proline, (S)-α-(2-bromobenzyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-α-(2-Bromobenzyl)-Proline-Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and development use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.