Description

3H-Pyrrolo[1,2-A]Azepin-3-One,1,2,5,8,9,9A-Hexahydro-,(9Ar)-(9Ci) is a high-purity, advanced pharmaceutical intermediate belonging to a class of complex heterocyclic compounds. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology research. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a key chiral scaffold in the synthesis of complex drug candidates, especially for neurological and oncological targets.
• Medicinal Chemistry Research: Used as a versatile building block for constructing novel molecular libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for new chemical entities (NCEs).
• Academic Research: Utilized in universities and research institutes for studying heterocyclic chemistry, asymmetric synthesis, and reaction mechanisms.
• Fine Chemical Synthesis: Acts as a precursor for other specialty chemicals and complex organic molecules requiring its unique fused ring structure.

Basic Information

Product Name	3H-Pyrrolo[1,2-A]Azepin-3-One,1,2,5,8,9,9A-Hexahydro-,(9Ar)-(9Ci)
CAS No.	633294-93-6
Molecular Formula	C10H13NO
Molecular Weight	163.22 g/mol
Synonyms	(9aR)-1,2,5,8,9,9a-Hexahydro-3H-pyrrolo[1,2-a]azepin-3-one; (9aR)-Octahydropyrrolo[1,2-a]azepin-3-one; (R)-1,2,5,8,9,9a-Hexahydro-3H-pyrrolo[1,2-a]azepin-3-one; Pyrroloazepinone derivative; Fused bicyclic lactam; Chiral pyrroloazepinone.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for research and development. Quality is verified through comprehensive analytical techniques including HPLC, GC, chiral analysis, and NMR to confirm identity, purity, and enantiomeric excess. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.