Description

1-Bromo-4-Fluoro-2-Methanesulfonylbenzene is a high-purity, multi-functional aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromo, fluoro, and methanesulfonyl substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aryl motifs for bioactivity or as coupling partners in cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine and bromine atoms can enhance metabolic stability and binding affinity.
• Material Science Research: Serves as a building block for creating advanced organic materials, such as liquid crystals, organic semiconductors, and polymers with specific electronic properties.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Sulfone Chemistry: The methanesulfonyl group can participate in various transformations, including as a directing group in metalation reactions or as a precursor for sulfinate salts.
• Chemical Biology & Proteomics: Potential use in designing activity-based probes or affinity labels due to its electrophilic sulfonyl moiety and halogen for further functionalization.

Basic Information

Product Name	1-Bromo-4-Fluoro-2-Methanesulfonylbenzene
CAS No.	628692-10-4
Molecular Formula	C7H6BrFO2S
Molecular Weight	253.09 g/mol
Synonyms	2-Bromo-5-fluorophenyl methyl sulfone; 1-Bromo-4-fluoro-2-(methylsulfonyl)benzene; 2-Bromo-5-fluorobenzene-1-sulfonylmethane; 5-Fluoro-2-bromophenyl methyl sulfone; Benzene, 1-bromo-4-fluoro-2-(methylsulfonyl)-; Methyl 2-bromo-5-fluorophenyl sulfone
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Fluoro-2-Methanesulfonylbenzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and process chemistry. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity and impurity profiles. Our quality management system is designed to support cGMP compliance for advanced intermediates, and we can accommodate custom purity specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.