Description

2-(2,5-Dioxo-Pyrrolidin-3-Ylsulfanyl)-Nicotinic Acid is a high-purity, specialized heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring both a nicotinic acid moiety and a maleimide-like pyrrolidinedione ring, makes it a versatile intermediate for constructing complex pharmacophores and functional materials. This compound is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and material science industries for applications in drug discovery, ligand synthesis, and the development of novel polymers or covalent inhibitors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies and covalent drug candidates.
• Bioconjugation & Linker Chemistry: Used to create bioconjugates, antibody-drug conjugates (ADCs), or protein-labeling reagents, leveraging the reactive maleimide group for thiol coupling.
• Polymer & Material Science: Serves as a functional monomer or cross-linking agent for synthesizing advanced polymers with specific thermal or mechanical properties.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, or plant growth regulators requiring complex heterocyclic cores.
• Chemical Biology Probes: Utilized to develop activity-based probes (ABPs) or affinity labels for studying enzyme function and target engagement.
• Academic & Contract Research: A valuable reagent for methodological development and exploratory synthesis in university and CRO laboratory settings.

Basic Information

Product Name	2-(2,5-Dioxo-Pyrrolidin-3-Ylsulfanyl)-Nicotinic Acid
CAS No.	626222-53-5
Molecular Formula	C10H8N2O4S
Molecular Weight	252.25 g/mol
Synonyms	3-((6-Carboxypyridin-2-yl)thio)-2,5-dihydro-1H-pyrrole-2,5-dione; 2-[(2,5-Dioxo-3-pyrrolidinyl)thio]nicotinic acid; 2-(2,5-Dioxopyrrolidin-3-ylsulfanyl)pyridine-3-carboxylic acid; Nicotinic acid, 2-[(2,5-dioxo-3-pyrrolidinyl)thio]-; 626222-53-5; 2-(2,5-Dioxo-3-pyrrolidinylthio)nicotinic Acid
EINECS	Contact for details

Quality Control

Our 2-(2,5-Dioxo-Pyrrolidin-3-Ylsulfanyl)-Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.