Description

8-Bromo-3,4-Dihydro-2H-Benzo[1,4]Oxazine Hydrochloride is a high-purity, synthetically valuable organic building block and pharmaceutical intermediate. This compound is crucial for medicinal chemistry research and development, particularly in the synthesis of novel heterocyclic compounds. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Agrochemical Synthesis: Serves as a building block for developing new active ingredients in crop protection agents.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce functionalized benzoxazine motifs.
• Chemical Biology Probe Development: Useful for creating tool compounds to study biological pathways and protein functions.
• Material Science Precursor: Potential intermediate in the synthesis of specialty polymers or organic electronic materials.

Basic Information

Product Name	8-Bromo-3,4-Dihydro-2H-Benzo[1,4]Oxazine Hydrochloride
CAS No.	625394-66-3
Molecular Formula	C8H9BrClNO
Molecular Weight	250.52 g/mol
Synonyms	8-Bromo-3,4-dihydro-2H-1,4-benzoxazine hydrochloride; 2H-1,4-Benzoxazine, 8-bromo-3,4-dihydro-, hydrochloride; 8-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine HCl; 8-Bromodihydrobenzoxazine hydrochloride; 8-Bromo-2H-1,4-benzoxazine-3(4H)-one hydrochloride (tautomer); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 8-Bromo-3,4-Dihydro-2H-Benzo[1,4]Oxazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.