Description

4-Chloro-6,7-difluoroquinazoline is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its role as a versatile and reactive scaffold for constructing complex pharmaceutical intermediates and active ingredients. This compound is primarily needed by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tyrosine kinase inhibitors (TKIs) and other small-molecule drug candidates targeting various cancers and proliferative diseases.
• Agrochemical Synthesis: Used as a building block for developing novel herbicides, fungicides, and pesticides with enhanced efficacy and selectivity.
• Chemical Research & Development: Serves as a critical starting material for medicinal chemistry programs, enabling structure-activity relationship (SAR) studies and lead optimization.
• Material Science: Potential application in the synthesis of organic electronic materials, such as charge-transport layers or light-emitting components, due to the quinazoline core's electronic properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and advanced intermediates under cGMP conditions.

Basic Information

Product Name	4-Chloro-6,7-difluoroquinazoline
CAS No.	625080-60-6
Molecular Formula	C8H3ClF2N2
Molecular Weight	200.57 g/mol
Synonyms	6,7-Difluoro-4-chloroquinazoline; 4-Chloro-6,7-difluoro-quinazoline; Quinazoline, 4-chloro-6,7-difluoro-; 4-Chlor-6,7-difluorchinazolin (German); 4-クロロ-6,7-ジフルオロキナゾリン (Japanese); 4-氯-6,7-二氟喹唑啉 (Chinese); 4-Chloro-6,7-difluoro-1,3-diazanaphthalene
EINECS	Contact for details

Quality Control

Our 4-Chloro-6,7-difluoroquinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. The container should be kept tightly sealed in a dry environment to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.