Description

4-Chloro-8-Nitro-Quinoline-3-Carbonitrile is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on novel active ingredients, including kinase inhibitors and other biologically relevant heterocycles.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel quinoline-based drug candidates, particularly in oncology and anti-infective research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides, leveraging its reactive nitro and cyano groups for structural diversification.
• Material Science Research: Serves as a precursor for creating specialized organic ligands, dyes, or photoactive materials due to its conjugated quinoline core.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and cellular pathways.
• Academic & Industrial R&D: A versatile scaffold for method development and library synthesis in medicinal and combinatorial chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring high-purity, complex intermediates.

Basic Information

Product Name	4-Chloro-8-Nitro-Quinoline-3-Carbonitrile
CAS No.	623163-11-1
Molecular Formula	C₁₀H₄ClN₃O₂
Molecular Weight	233.61 g/mol
Synonyms	8-Nitro-4-chloroquinoline-3-carbonitrile; 4-Chloro-8-nitroquinoline-3-carbonitrile; 3-Cyano-4-chloro-8-nitroquinoline; Quinoline-3-carbonitrile, 4-chloro-8-nitro-; 623163-11-1; 4-Chloro-8-nitro-3-quinolinecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-8-Nitro-Quinoline-3-Carbonitrile is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.