Description

4-[(2,4-Dichloro-5-Methoxyphenyl)Amino]-7-Fluoro-6-Methoxy-3-Quinolinecarbonitrile is a high-purity, advanced pharmaceutical intermediate belonging to the quinolinecarbonitrile class of compounds. This specialty chemical is critical for the synthesis of targeted therapeutic agents, offering a precise molecular scaffold for drug discovery and development. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the creation of novel small-molecule drugs, particularly in oncology and other therapeutic areas requiring complex heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for investigational drugs.
• Drug Discovery Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization, particularly for kinase inhibitors.
• Oncology Research: Functions as a core scaffold in the development of targeted cancer therapies due to its quinoline-based structure.
• Chemical Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry Development: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and development services for the pharmaceutical industry.

Basic Information

Product Name	4-[(2,4-Dichloro-5-Methoxyphenyl)Amino]-7-Fluoro-6-Methoxy-3-Quinolinecarbonitrile
CAS No.	622369-46-4
Molecular Formula	C18H12Cl2FN3O2
Molecular Weight	392.21 g/mol
Synonyms	7-Fluoro-6-methoxy-4-[(2,4-dichloro-5-methoxyphenyl)amino]quinoline-3-carbonitrile; 4-((2,4-Dichloro-5-methoxyphenyl)amino)-7-fluoro-6-methoxyquinoline-3-carbonitrile; 622369-46-4; UNII-9Q8J1J8F8M; 9Q8J1J8F8M; BDBM50388885; AKOS025310923; A-841720; ZINC000003869756; 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile
EINECS	Contact for details

Quality Control

Our production of 4-[(2,4-Dichloro-5-Methoxyphenyl)Amino]-7-Fluoro-6-Methoxy-3-Quinolinecarbonitrile adheres to stringent quality management systems, ensuring batch-to-batch consistency for research and development applications. The material is characterized and released according to comprehensive in-house specifications, which typically include identity confirmation by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing lot-specific results is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.