Description

4-Chloro-7-Fluoro-6-Methoxy-Quinoline-3-Carbonitrile is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique halogenated quinoline scaffold makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, anticancer agents, and other biologically active quinoline derivatives.
• Agrochemical Synthesis: Used in the development of new-generation fungicides and herbicides, leveraging its halogen-substituted quinoline core.
• Material Science Research: Serves as a building block for creating organic semiconductors, luminescent materials, and advanced polymers.
• Chemical Biology & Proteomics: Employed as a scaffold for designing molecular probes and enzyme inhibitors in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules and reference standards.

Basic Information

Product Name	4-Chloro-7-Fluoro-6-Methoxy-Quinoline-3-Carbonitrile
CAS No.	622369-40-8
Molecular Formula	C₁₁H₆ClFN₂O
Molecular Weight	236.63 g/mol
Synonyms	4-Chloro-7-fluoro-6-methoxyquinoline-3-carbonitrile; 6-Methoxy-7-fluoro-4-chloroquinoline-3-carbonitrile; 3-Cyano-4-chloro-7-fluoro-6-methoxyquinoline; Quinoline-3-carbonitrile, 4-chloro-7-fluoro-6-methoxy-; 622369-40-8; 4-Chloro-7-fluoro-6-methoxy-3-quinolinecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-7-Fluoro-6-Methoxy-Quinoline-3-Carbonitrile is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and compliance with your project requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.