Description

4-[(2,4-Dichloro-5-Methoxyphenyl)Amino]-6-Methoxy-7-[(1-Methyl-4-Piperidin-4-Yl)Methoxy]-3 Quinolinecarbonitrile is a high-purity, advanced pharmaceutical intermediate designed for critical synthesis pathways. This compound is valued for its role as a key building block in the development of targeted therapeutic agents, particularly kinase inhibitors. It is essential for research and development laboratories, process chemistry teams, and manufacturers in the pharmaceutical and biotechnology sectors requiring reliable, high-quality intermediates for complex API synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel kinase inhibitor drug candidates.
• Oncology Research: Used in the development and scale-up of targeted cancer therapies due to its specific quinolinecarbonitrile scaffold.
• Process Chemistry & Scale-Up: Serves as a defined starting material or intermediate for process optimization and commercial manufacturing of Active Pharmaceutical Ingredients (APIs).
• Biochemical Research: Employed in structure-activity relationship (SAR) studies to explore and modify biological activity profiles.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations for cGMP production of clinical trial materials and commercial drugs.

Basic Information

Product Name	4-[(2,4-Dichloro-5-Methoxyphenyl)Amino]-6-Methoxy-7-[(1-Methyl-4-Piperidin-4-Yl)Methoxy]-3 Quinolinecarbonitrile
CAS No.	622369-21-5
Molecular Formula	C25H26Cl2N4O3
Molecular Weight	501.40 g/mol
Synonyms	4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinoline-3-carbonitrile; 7-[(1-Methyl-4-piperidinyl)methoxy]-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile; Kinase Inhibitor Intermediate; Quinolinecarbonitrile Derivative; CAS 622369-21-5
EINECS	Contact for details

Quality Control

Our production of 4-[(2,4-Dichloro-5-Methoxyphenyl)Amino]-6-Methoxy-7-[(1-Methyl-4-Piperidin-4-Yl)Methoxy]-3 Quinolinecarbonitrile adheres to stringent quality systems suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere if specified.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.