Description

(R)-(-)-4,12-Bis(Di-3,5-Xylylphosphino)[2.2]Paracyclophane(1,5-Cyclooctadiene)Rhodium(I) Tetrafluoroborate is a highly specialized, chiral rhodium complex used as a homogeneous catalyst for asymmetric synthesis. This compound matters for its ability to induce high enantioselectivity in critical carbon-carbon and carbon-heteroatom bond-forming reactions, enabling the production of single-enantiomer intermediates. It is essential for R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control to develop new active ingredients and advanced materials.

Application

• Asymmetric Hydrogenation: A premier catalyst for the enantioselective reduction of prochiral olefins, enamides, and ketones to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in active pharmaceutical ingredients (APIs), including those for cardiovascular, CNS, and antiviral drugs.
• Agrochemical Manufacturing: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Fragrance Production: Enables the asymmetric synthesis of complex chiral molecules for high-value flavors, fragrances, and specialty chemicals.
• Academic and Industrial R&D: A valuable tool for methodological development in organic synthesis and process chemistry within research laboratories.
• Asymmetric C-H Functionalization: Employed in cutting-edge catalytic transformations for the direct, enantioselective modification of C-H bonds.

Basic Information

Product Name	(R)-(-)-4,12-Bis(Di-3,5-Xylylphosphino)[2.2]Paracyclophane(1,5-Cyclooctadiene)Rhodium(I) Tetrafluoroborate
CAS No.	619334-93-9
Molecular Formula	C64H64BF4P2Rh
Molecular Weight	1064.84 g/mol
Synonyms	(R)-Walphos Rh(I) Tetrafluoroborate; (R)-(-)-4,12-Bis(di-3,5-xylylphosphino)[2.2]paracyclophane(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; Rhodium(I) (R)-Walphos catalyst; (R)-Walphos(COD)RhBF4; (R)-4,12-Bis[bis(3,5-dimethylphenyl)phosphino][2.2]paracyclophane(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; Asymmetric hydrogenation catalyst (R)-Walphos Rh; (R)-Walphos-Rh(COD)BF4
EINECS	Contact for details

Quality Control

Every batch of our chiral catalyst is synthesized and handled under strict inert atmosphere conditions to preserve its catalytic activity and enantioselectivity. Quality is verified through a comprehensive suite of analytical techniques including NMR (¹H, ³¹P, ¹⁹F), HPLC for chiral purity, and elemental analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and performance in standard test reactions.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Chiral Purity (HPLC)	≥ 99% ee
Rhodium Content	9.0 - 10.5 %
Solubility	Soluble in dichloromethane, chloroform, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.