Description

JWH 116 is a synthetic cannabinoid receptor agonist of significant interest in pharmacological research. Its precise molecular structure makes it a valuable reference standard and a key intermediate for the development of novel chemical entities. This compound is primarily utilized by research institutions and pharmaceutical development laboratories focused on studying the endocannabinoid system. The product is supplied as JWH 116 CAS NO 619294-64-3, ensuring researchers receive a well-defined material for their critical work.

Application

• Pharmacological Research: Used as a reference standard and tool compound in studies investigating cannabinoid receptor (CB1/CB2) activity and signaling pathways.
• Biochemical Assay Development: Serves as a key ligand in the development and validation of high-throughput screening assays for receptor binding studies.
• Metabolic Pathway Analysis: Employed in in vitro and in vivo studies to understand the metabolism and pharmacokinetics of synthetic cannabinoids.
• Analytical Method Development: Acts as a primary standard for calibrating analytical instruments (HPLC, GC-MS, LC-MS) in forensic and clinical toxicology laboratories.
• Medicinal Chemistry: Functions as a crucial synthetic intermediate or a structural template for designing new chemical entities with potential therapeutic applications.
• Forensic Science: Used for the identification and quantification of novel psychoactive substances (NPS) in casework and regulatory compliance testing.

Basic Information

Product Name	JWH 116
CAS No.	619294-64-3
Molecular Formula	C24H23NO
Molecular Weight	341.45 g/mol
Synonyms	1-Pentyl-3-(1-naphthoyl)indole; 1-Pentyl-1H-indol-3-yl-(1-naphthyl)methanone; JWH-116; JWH 116; Naphthalen-1-yl(1-pentyl-1H-indol-3-yl)methanone; (1-Pentylindol-3-yl)-1-naphthylmethanone; AM-1220 azepane isomer (common misidentification); Synthetic cannabinoid AM-1220 analog
EINECS	Contact for details

Quality Control

Our JWH 116 is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light tan crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.