Description

Ecgonine-D3 Hcl is a deuterated isotopologue of the tropane alkaloid ecgonine, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is of critical importance for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical results. It is primarily required by analytical laboratories, forensic science institutions, and pharmaceutical R&D departments engaged in method development and validation for the precise detection and quantification of related alkaloids.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical reference compound in LC-MS/MS and GC-MS methods for the quantification of cocaine and its metabolites in forensic, clinical, and toxicological studies.
• Forensic Analysis & Drug Testing: Enables accurate and legally defensible measurement of controlled substances in biological matrices (urine, blood, hair) and seized materials.
• Pharmaceutical Research: Used in pharmacokinetic and metabolic studies to track the absorption, distribution, metabolism, and excretion (ADME) of tropane alkaloid derivatives.
• Method Development & Validation: Essential for developing, optimizing, and validating highly sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control & Reference Material: Acts as a certified reference material (CRM) for calibrating instruments and ensuring the quality and consistency of analytical data.
• Isotope Dilution Analysis: Employed in precise quantitative techniques to correct for analyte loss during sample preparation and matrix effects.

Basic Information

Product Name	Ecgonine-D3 Hcl
CAS No.	115144-41-7
Molecular Formula	C9H12D3ClNO3
Molecular Weight	Approx. 235.69 g/mol
Synonyms	Ecgonine-d3 hydrochloride; (-)-Ecgonine-d3 hydrochloride; 3-Hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid-d3 hydrochloride; 2-Carboxy-3-tropanol-d3 hydrochloride; Benzoylecgonine precursor-d3 HCl; Tropane-2-carboxylic acid, 3-hydroxy-, methyl-, hydrochloride-d3; 8-Methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, 3-hydroxy-, hydrochloride-d3
EINECS	Contact for details

Quality Control

Our Ecgonine-D3 Hcl is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch undergoes rigorous testing, including HPLC for chemical purity, NMR and MS for structural confirmation and isotopic enrichment, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.