Description

1-(3-Chloro-4-Fluorophenyl)-3-(4-Fluorophenyl)-1H-Pyrazole-5-Carboxylic Acid is a high-purity, multi-fluorinated pyrazole carboxylic acid derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique halogenated aromatic structure, which is essential for constructing complex molecules with targeted biological and material properties. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for the development of new active pharmaceutical ingredients (APIs) and high-performance agrochemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in kinase inhibitor and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging its fluorinated structure for enhanced bioactivity and stability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals where fluorine substitution is required for specific electronic or surface properties.
• Chemical Biology Probes: Employed in the design of molecular probes and tags for studying biological processes due to its modifiable carboxylic acid group.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity fluorinated intermediates.

Basic Information

Product Name	1-(3-Chloro-4-Fluorophenyl)-3-(4-Fluorophenyl)-1H-Pyrazole-5-Carboxylic Acid
CAS No.	618102-76-4
Molecular Formula	C16H9ClF2N2O2
Molecular Weight	334.71 g/mol
Synonyms	5-Carboxy-1-(3-chloro-4-fluorophenyl)-3-(4-fluorophenyl)pyrazole; 1-(3-Chloro-4-fluorophenyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid; 1H-Pyrazole-5-carboxylic acid, 1-(3-chloro-4-fluorophenyl)-3-(4-fluorophenyl)-; 618102-76-4; 3-(4-Fluorophenyl)-1-(3-chloro-4-fluorophenyl)-1H-pyrazole-5-carboxylic acid; 1-(3-Chloro-4-fluorophenyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid (CAS 618102-76-4)
EINECS	Contact for details

Quality Control

Our 1-(3-Chloro-4-Fluorophenyl)-3-(4-Fluorophenyl)-1H-Pyrazole-5-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure compliance with exacting industry standards. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.