Description

(S)-Diethyl 2-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-Yloxy)Quinazolin-6-Ylamino)-2-Oxoethylphosphonate is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key chiral building block in the synthesis of targeted kinase inhibitors, offering critical structural complexity for drug discovery programs. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of novel oncology and therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of targeted anticancer agents, particularly tyrosine kinase inhibitors.
• Drug Discovery & Development: Used in medicinal chemistry research for structure-activity relationship (SAR) studies and lead optimization.
• Biochemical Research: Serves as a reference standard or tool compound in enzymatic assays and biological pathway studies.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for the preparation of more complex, proprietary drug candidates and analogs.

Basic Information

Product Name	(S)-Diethyl 2-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-Yloxy)Quinazolin-6-Ylamino)-2-Oxoethylphosphonate
CAS No.	618061-76-0
Molecular Formula	C25H29ClFN4O6P
Molecular Weight	573.95 g/mol
Synonyms	(S)-Diethyl (2-((4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate; (S)-Diethyl (2-((4-((3-Chloro-4-fluorophenyl)amino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate; 618061-76-0; (S)-Enantiomer of Diethyl 2-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-Yloxy)Quinazolin-6-Ylamino)-2-Oxoethylphosphonate; UNII-6K8I3KJ1Q8; 6K8I3KJ1Q8; AKOS040757625; SCHEMBL21806427; BDBM50381723
EINECS	Contact for details

Quality Control

Our (S)-Diethyl 2-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-Yloxy)Quinazolin-6-Ylamino)-2-Oxoethylphosphonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, NMR, and LC-MS for identity confirmation and impurity profiling. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.