Description

1,3-Dioxolane, 4,5-Diethynyl-2,2-Dimethyl-, (4S,5S)- (9Ci) is a high-value, stereochemically defined chiral building block featuring a protected diol core with terminal alkyne functionalities. This compound matters for its role as a versatile synthetic intermediate, enabling the construction of complex molecular architectures with precise stereochemical control. It is primarily needed by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for applications in asymmetric synthesis, ligand development, and polymer chemistry. CAS number 617704-38-8.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) and complex natural product analogs.
• Asymmetric Catalysis: Precursor for the development of novel chiral ligands and catalysts used in enantioselective transformations.
• Click Chemistry: The terminal alkyne groups are ideal for Huisgen 1,3-dipolar cycloaddition reactions, facilitating bioconjugation and polymer functionalization.
• Advanced Material Synthesis: Building block for specialty polymers, dendrimers, and molecular frameworks with tailored properties.
• Organic Electronic Materials: Potential precursor for conjugated systems used in organic light-emitting diodes (OLEDs) or semiconductors.
• Chemical Biology Probes: Used to create tagged molecules for studying biological processes and target engagement.

Basic Information

Item	Detail
Product Name	1,3-Dioxolane, 4,5-Diethynyl-2,2-Dimethyl-, (4S,5S)- (9Ci)
CAS No.	617704-38-8
Molecular Formula	C9H10O2
Molecular Weight	150.17 g/mol
Synonyms	(4S,5S)-4,5-Diethynyl-2,2-dimethyl-1,3-dioxolane; (4S,5S)-2,2-Dimethyl-4,5-diethynyl-1,3-dioxolane; (S,S)-4,5-Diethynyl-2,2-dimethyl-1,3-dioxolane; Chiral diethynyldioxolane; Acetylene-protected chiral diol; 1,3-Dioxolane, 4,5-diethynyl-2,2-dimethyl-, (4S-cis)-; (4S,5S)-Diethynyl-2,2-dimethyl-1,3-dioxolane
EINECS	Contact for details

Quality Control

This high-purity chiral building block is produced under strict quality control protocols to ensure batch-to-batch consistency and stereochemical integrity. Quality is verified by advanced analytical techniques including Chiral HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, it is recommended to keep the material under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.