Description

4-(3-Chloro-2-Fluoroanilino)-6-Hydroxy-7-Methoxyquinazoline is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This quinazoline derivative is a critical building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is essential for R&D laboratories and pharmaceutical manufacturers engaged in the development of novel oncology and anti-inflammatory treatments. The compound, identified by CAS number 612501-52-7, is supplied under stringent quality control to ensure batch-to-batch consistency for sensitive synthetic pathways.

Application

This specialized quinazoline intermediate serves as a key precursor in several high-value chemical syntheses. Its primary and related applications include:

• Pharmaceutical Intermediate: Core building block for the synthesis of tyrosine kinase inhibitor (TKI) drug candidates.
• Oncology Research: Used in the R&D of small molecule therapies targeting specific cancer cell pathways.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in API manufacturing.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and novel compound library generation.

Basic Information

Item	Detail
Product Name	4-(3-Chloro-2-Fluoroanilino)-6-Hydroxy-7-Methoxyquinazoline
CAS No.	612501-52-7
Molecular Formula	C₁₅H₁₁ClFN₃O₂
Molecular Weight	319.72 g/mol
Synonyms	6-Hydroxy-7-methoxy-4-[(3-chloro-2-fluorophenyl)amino]quinazoline; 4-[(3-Chloro-2-fluorophenyl)amino]-6-hydroxy-7-methoxyquinazoline; 612501-52-7; 4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7-methoxyquinazoline; Quinazoline, 4-[(3-chloro-2-fluorophenyl)amino]-6-hydroxy-7-methoxy-
EINECS	Contact for details

Quality Control

Our production of 4-(3-Chloro-2-Fluoroanilino)-6-Hydroxy-7-Methoxyquinazoline adheres to a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy. We provide a Certificate of Analysis (COA) with each shipment, detailing all specified parameters to ensure the material meets the rigorous standards required for pharmaceutical development and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled and stored away from direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.