Description

n-(3-Chloro-2-Fluorophenyl)-7-Methoxy-6-(Piperidin-4-Yloxy)Quinazolin-4-Amine is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of compounds. This compound is of significant commercial importance due to its role as a key building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel oncology and anti-inflammatory treatments.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent and selective kinase inhibitors for targeted cancer therapies.
• Oncology Drug Discovery: Used in research and development (R&D) for creating novel small-molecule drugs targeting specific signaling pathways in cancer cells.
• Biochemical Research: Serves as a reference standard or a tool compound in enzymatic assays and pharmacological studies to investigate kinase activity and inhibition.
• Process Chemistry & Scale-Up: Employed in process development and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Custom Synthesis: Utilized by fine chemical suppliers for the custom synthesis of more complex, proprietary drug candidates for client partners.

Basic Information

Item	Detail
Product Name	n-(3-Chloro-2-Fluorophenyl)-7-Methoxy-6-(Piperidin-4-Yloxy)Quinazolin-4-Amine
CAS No.	612500-78-4
Molecular Formula	C20H20ClFN4O2
Molecular Weight	402.85 g/mol
Synonyms	6-[(Piperidin-4-yl)oxy]-7-methoxy-N-(3-chloro-2-fluorophenyl)quinazolin-4-amine; 612500-78-4; 4-Quinazolinamine, N-(3-chloro-2-fluorophenyl)-7-methoxy-6-(4-piperidinyloxy)-; N-(3-Chloro-2-fluorophenyl)-7-methoxy-6-(piperidin-4-yloxy)quinazolin-4-amine; 6-(Piperidin-4-yloxy)-7-methoxy-N-(3-chloro-2-fluorophenyl)quinazolin-4-amine; PF-06463922 Intermediate; Lorlatinib Intermediate
EINECS	Contact for details

Quality Control

Our production of n-(3-Chloro-2-Fluorophenyl)-7-Methoxy-6-(Piperidin-4-Yloxy)Quinazolin-4-Amine adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. The material is manufactured under controlled conditions and undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.