Description

Neu5Troc[1Me,4789Ac]Alpha(2-3)Gal[26Bn]-β-Mp is a synthetically engineered sialylated glycoside derivative designed for precision glycoconjugate synthesis and glycobiology research. It serves as a critical building block for the chemoenzymatic preparation of complex sialylated glycans, enabling high-fidelity studies of sialic acid–mediated molecular recognition in therapeutic antibody optimization and vaccine development. This compound is essential for pharmaceutical R&D laboratories, biotech CDMOs, and academic glycobiology centers requiring rigorously defined, functionally validated glycan intermediates.

Application

• Chemoenzymatic synthesis of sialylated glycoconjugates for monoclonal antibody glycoengineering
• Substrate for sialyltransferase enzyme assays and inhibitor screening
• Building block in the preparation of glycan microarrays for lectin-binding profiling
• Intermediate in the synthesis of tumor-associated carbohydrate antigens (e.g., GD3, GT3 mimetics)
• Tool compound for studying Siglec–ligand interactions in immunomodulation research
• Reference standard in LC-MS/MS-based glycomics workflows
• Development of sialidase-resistant glycotherapeutics via Troc/Me/Ac/Bn protecting group strategy
• Glycan-based diagnostic probe synthesis for infectious disease biomarker detection

Basic Information

Product Name	Neu5Troc[1Me,4789Ac]Alpha(2-3)Gal[26Bn]-β-Mp
CAS No.	610763-72-9
Molecular Formula	C57H75NO25
Molecular Weight	1222.18 g/mol
Synonyms	Neu5Trocα(2-3)Galβ-pNP; 3'-O-(N-Troc-5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosyl)-4-O-benzyl-1-thio-β-D-galactopyranoside; Neu5Troc[1-Me,4,7,8,9-tetra-O-acetyl]α(2→3)[2',6'-di-O-benzyl]β-D-galactopyranosyl β-p-nitrophenyl glycoside; Sialyl α(2-3) galactoside p-nitrophenyl derivative with Troc/Me/Ac/Bn protection; 3′-Sialyl-N-trichloroethoxycarbonyl-4,7,8,9-tetra-O-acetyl-1-methyl-sialic acid α(2-3)-2′,6′-dibenzyl-galactoside; Neu5Troc(Me)(Ac)4α2-3Gal(Bn)2β-pNP; α-Neu5Troc[1-Me,4,7,8,9-Ac4]-(2→3)-β-D-Gal-(2′,6′-di-O-Bn)-p-nitrophenyl glycoside
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is verified for identity (IR, NMR, HPLC), purity (≥98.5% by HPLC), residual solvents (ICH Q3C compliant), and stereochemical integrity (specific optical rotation). Certificates of Analysis (COA) are available upon request and include full chromatographic traces, spectral data, and heavy metal testing (≤10 ppm total metals). Manufacturing adheres to ISO 9001-certified processes and supports GMP-compliant downstream use.

Storage

Preserve in a tightly closed container, protected from light. Store at −20 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, minimize exposure to ambient humidity; allow container to equilibrate to room temperature before opening. Handle in a controlled environment with low relative humidity (<30% RH) and use immediately after dissolution.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identity (IR)	Conforms to reference spectrum
Identity (NMR)	1H and 13C NMR consistent with structure
Assay (HPLC)	≥98.5%
Single Impurity (HPLC)	≤0.5%
Optical Rotation [α]D20	−28° to −32° (c = 1.0 in CHCl3)
Residual Solvents (GC)	MeOH ≤0.3%, CH2Cl2 ≤0.5%, THF ≤0.1% (ICH Q3C)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.