Description

n-(3-Chloro-4-Fluorophenyl)-7-Methoxy-6-((Tetrahydro-2H-Pyran-4-Yl)Oxy)Quinazolin-4-Amine is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors, due to its complex quinazoline-based molecular architecture. It is essential for pharmaceutical R&D laboratories and manufacturers engaged in developing novel treatments for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted small-molecule drugs, especially tyrosine kinase inhibitors (TKIs).
• Oncology Drug Development: Serves as a core scaffold for research and production of potential anti-cancer therapeutics.
• Biochemical Research: Used as a reference standard or a probe compound in enzymatic and cellular assays to study kinase signaling pathways.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale manufacturing for clinical trial material (CTM) production.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for proprietary client synthesis projects.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry programs and structure-activity relationship (SAR) studies.

Basic Information

Product Name	n-(3-Chloro-4-Fluorophenyl)-7-Methoxy-6-((Tetrahydro-2H-Pyran-4-Yl)Oxy)Quinazolin-4-Amine
CAS No.	609767-39-7
Molecular Formula	C20H19ClFN3O3
Molecular Weight	403.84 g/mol
Synonyms	7-Methoxy-6-((tetrahydro-2H-pyran-4-yl)oxy)-N-(3-chloro-4-fluorophenyl)quinazolin-4-amine; 609767-39-7; 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[(tetrahydro-2H-pyran-4-yl)oxy]-; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(tetrahydropyran-4-yloxy)quinazolin-4-amine; 6-(Oxan-4-yloxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine
EINECS	Contact for details

Quality Control

Our n-(3-Chloro-4-Fluorophenyl)-7-Methoxy-6-((Tetrahydro-2H-Pyran-4-Yl)Oxy)Quinazolin-4-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.