Description

Acetamide, n-(1,1-Dimethylethyl)-2-[[2-(4-Fluorophenyl)-8-Methyl-4-Quinazolinyl]Thio]- (9Ci) is a high-purity, advanced pharmaceutical intermediate designed for research and development. This compound is critical for medicinal chemists and process development scientists working on novel therapeutic agents, particularly in oncology and targeted disease areas. Its complex quinazoline-thioacetamide structure makes it a valuable building block for synthesizing potential drug candidates, offering a reliable and consistent starting point for critical pharmaceutical innovation.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Oncology Drug Development: Serves as a critical intermediate in the synthesis of experimental compounds targeting specific cancer pathways.
• Process Chemistry & Scale-Up: Employed in route scouting, process optimization, and the pilot-scale manufacturing of investigational new drugs (INDs).
• Biochemical Research: May be utilized as a tool compound or a ligand in biochemical assays to study enzyme inhibition and cellular signaling mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules under cGMP or non-GMP conditions.

Basic Information

Item	Detail
Product Name	Acetamide, n-(1,1-Dimethylethyl)-2-[[2-(4-Fluorophenyl)-8-Methyl-4-Quinazolinyl]Thio]- (9Ci)
CAS No.	606131-48-0
Molecular Formula	C21H22FN3OS
Molecular Weight	383.48 g/mol
Synonyms	N-(tert-Butyl)-2-((2-(4-fluorophenyl)-8-methylquinazolin-4-yl)thio)acetamide; 2-[[2-(4-Fluorophenyl)-8-methyl-4-quinazolinyl]thio]-N-(1,1-dimethylethyl)acetamide; tert-Butyl 2-((2-(4-fluorophenyl)-8-methylquinazolin-4-yl)thio)acetamide; Acetamide, N-(1,1-dimethylethyl)-2-[[2-(4-fluorophenyl)-8-methyl-4-quinazolinyl]thio]-; CAS 606131-48-0
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and tested under a strict quality management system. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring full traceability and compliance with your research or development protocols. Our commitment to consistent high purity and reliable supply is paramount for your critical pharmaceutical R&D workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The material should be kept under an inert atmosphere if long-term stability is required. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.