Description

6-Benzyl-5,6,7,8-Tetrahydro-2,6-Naphthyridin-1(2H)-One is a high-purity, advanced pharmaceutical intermediate belonging to the naphthyridine class of heterocyclic compounds. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and oncological pathways. Pharmaceutical R&D teams and fine chemical manufacturers need it to develop and scale up production of next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core scaffold for the development of new APIs with potential kinase inhibitory or receptor-modulating activity.
• Medicinal Chemistry & Research: Used in structure-activity relationship (SAR) studies and lead optimization processes within contract research organizations (CROs) and academic labs.
• Process Chemistry & Scale-Up: Employed in process development and pilot-scale manufacturing for establishing robust, GMP-compliant synthetic routes.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	6-Benzyl-5,6,7,8-Tetrahydro-2,6-Naphthyridin-1(2H)-One
CAS No.	601514-62-9
Molecular Formula	C₁₅H₁₆N₂O
Molecular Weight	240.30 g/mol
Synonyms	6-Benzyl-1,2,5,6,7,8-hexahydro-2,6-naphthyridin-1-one; 6-Benzyl-5,6,7,8-tetrahydro-2,6-naphthyridin-1(2H)-one; 1(2H)-Naphthyridinone, 5,6,7,8-tetrahydro-6-(phenylmethyl)-; 6-Benzyl-1,2,5,6,7,8-hexahydro-2,6-naphthyridin-1-one; Tetrahydro-2,6-naphthyridinone derivative
EINECS	Contact for details

Quality Control

Our 6-Benzyl-5,6,7,8-Tetrahydro-2,6-Naphthyridin-1(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.