Description

(1R,2R)-N,N'-Dimethyl-1,2-cyclohexanediamine is a high-purity, chiral diamine compound widely utilized as a versatile ligand and building block in asymmetric synthesis. Its primary commercial value lies in its ability to impart high enantioselectivity in catalytic reactions, which is critical for producing optically pure intermediates in the pharmaceutical and fine chemical industries. This product is essential for research and manufacturing chemists developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials where precise stereochemical control is required.

Application

• Asymmetric Catalysis: Serves as a key chiral ligand for transition metal catalysts (e.g., with Ru, Rh, Ir) in hydrogenation, transfer hydrogenation, and other enantioselective transformations.
• Pharmaceutical Intermediates: Critical building block for the synthesis of chiral drugs, including antiviral agents, cardiovascular medications, and central nervous system (CNS) therapeutics.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and pesticides to enhance efficacy and reduce environmental impact.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high stereochemical purity.
• Polymer & Material Science: Acts as a monomer or curing agent for developing novel polymers, epoxy resins, and chiral stationary phases for chromatography.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and process chemistry optimization.

Basic Information

Product Name	(1R,2R)-N,N'-Dimethyl-1,2-cyclohexanediamine
CAS No.	68737-65-5
Molecular Formula	C8H18N2
Molecular Weight	142.24 g/mol
Synonyms	(1R,2R)-(-)-1,2-Diamino-N,N-dimethylcyclohexane; (1R,2R)-N,N-Dimethyl-1,2-diaminocyclohexane; (1R,2R)-(-)-N,N'-Dimethyl-1,2-cyclohexanediamine; (1R,2R)-DACH-NMe2; (R,R)-(-)-N,N'-Dimethyl-1,2-diaminocyclohexane; (R,R)-DMCHD; N,N'-Dimethyl-(1R,2R)-1,2-cyclohexanediamine; (1R,2R)-N,N'-Dimethylcyclohexane-1,2-diamine
EINECS	Contact for details

Quality Control

Our (1R,2R)-N,N'-Dimethyl-1,2-cyclohexanediamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. Our quality protocols are designed to meet the stringent requirements of cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC or HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Specific Rotation [α]	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.